<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2020 Workiva-->
<!--r:2a3c7259-ad1b-411b-b672-d5f19ac70798,g:7eb7f896-882a-40ac-831a-e8fe42779cca-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.lantheus.com/role/Cover" xlink:type="simple" xlink:href="lnth-20200730.xsd#Cover"/>
  <link:calculationLink xlink:role="http://www.lantheus.com/role/Cover" xlink:type="extended"/>
</link:linkbase>
