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of Fiscal Year Trading Arrangement: Trading Arrangement [Axis] Liability measurement input, percentage Business Combination, Contingent Consideration, Liability, Measurement Input PEO Actually Paid Compensation Amount PEO Actually Paid Compensation Amount Leases Lessee, Finance Leases [Text Block] Machinery, equipment and fixtures Machinery Equipment And Fixtures [Member] Machinery Equipment And Fixtures [Member] Schedule of Income Tax Expense Schedule of Components of Income Tax Expense (Benefit) [Table Text Block] Long-term Debt, Type [Domain] Long-Term Debt, Type [Domain] Strategic partnerships and other revenue Strategic Partnerships And Other [Member] Strategic Partnerships And Other Entity File Number Entity File Number Stock option exercises and employee stock plan purchases Stock Issued During Period, Value, Stock Options Exercised and Employee Stock Ownership Plan Stock Issued During Period, Value, Stock Options Exercised and Employee Stock Ownership Plan Operating Operating 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Impairment of long-lived assets Asset Impairment Charges Contingent consideration liabilities Business Combination, Contingent Consideration, Liability Revenue from Contract with Customer [Abstract] Revenue from Contract with Customer [Abstract] All Individuals All Individuals [Member] Net sales targets - AZEDRA and 1095 Contingent Consideration, Net Sales Targets [Member] Contingent Consideration, Net Sales Targets Finance Lease, Right-of-Use Asset, Statement of Financial Position [Extensible Enumeration] Finance Lease, Right-of-Use Asset, Statement of Financial Position [Extensible Enumeration] Other (income) expense Total other (income) expense, net Other Nonoperating Income (Expense) Entity Filer Category Entity Filer Category Vesting of restricted stock awards and units Vesting Of Restricted Stock Awards Value, Net Vesting of restricted stock awards value. 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Individual Title Obligation expected to be incurred Asset Retirement Obligation Liabilities Expected Present Value Represents the amount of expected present value of asset retirement obligations. 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Exercise Price Finite-Lived Intangible Assets by Major Class [Axis] Finite-Lived Intangible Assets by Major Class [Axis] Potential payments, high Business Combination, Contingent Consideration Arrangements, Range of Outcomes, Value, High Disposal Group Classification [Axis] Disposal Group Classification [Axis] Statement of Cash Flows [Abstract] Statement of Cash Flows [Abstract] Assets Assets [Abstract] Award Timing MNPI Disclosure Award Timing MNPI Disclosure [Text Block] Earnings Per Share, Basic, by Common Class, Including Two Class Method [Line Items] Earnings Per Share, Basic, by Common Class, Including Two Class Method [Line Items] Goodwill and Intangible Assets Disclosure [Abstract] Goodwill and Intangible Assets Disclosure [Abstract] Total liabilities Liabilities, Fair Value Disclosure Foreign currency losses Gain (Loss), Foreign Currency Transaction, before Tax Debt instrument, covenant leverage ratio Debt Instrument, Covenant Leverage Ratio Debt Instrument, Covenant Leverage Ratio Payments for minimum statutory tax withholding related to net share settlement of equity awards Payment, Tax Withholding, Share-Based Payment Arrangement Liabilities Liabilities [Abstract] Financing activities Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] Operating Lease, Right-of-Use Asset, Statement of Financial Position [Extensible Enumeration] Operating Lease, Right-of-Use Asset, Statement of Financial Position [Extensible Enumeration] Total leased liabilities Lease Liability Lease Liability Net cash used in financing activities Net Cash Provided by (Used in) Financing Activities Deferred tax assets, net Deferred Income Tax Assets, Net Lessee, Lease, Description [Line Items] Lessee, Lease, Description [Line Items] Developed technology Developed Technology Rights [Member] Accumulated Deficit Retained Earnings [Member] Current portion of long-term debt and other borrowings Long-Term Debt, Current Maturities Gain on sale of RELISTOR licensed intangible asset associated with net sales royalties Proceeds From Sale Of Royalty Rights, Additional Payment Proceeds From Sale Of Royalty Rights, Additional Payment Schedule of Stock-Based Compensation Expense Recognized Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] Adjustment to Non-PEO NEO Compensation Footnote Adjustment to Non-PEO NEO Compensation Footnote [Text Block] Total liabilities and stockholders’ equity Liabilities and Equity Other long-term assets Other Assets, Noncurrent Peer Group Total Shareholder Return Amount Peer Group Total Shareholder Return Amount Operating Operating Lease, Right-of-Use Asset Basic (in dollars per share) Basic income per common share (in shares) Earnings Per Share, Basic Schedule of Long-term Debt Instruments [Table] Schedule of Long-Term Debt Instruments [Table] Accounting Policies [Abstract] Accounting Policies [Abstract] Equity Valuation Assumption Difference, Footnote Equity Valuation Assumption Difference, Footnote [Text Block] Gain on sale of RELISTOR licensed intangible asset associated with net sales royalties Gain on sale of RELISTOR licensed intangible asset associated with net sales royalties Gain (Loss) on Disposition of Assets Erroneous Compensation Analysis Erroneous Compensation Analysis [Text Block] Finance Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration] Finance Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration] Arrangement Duration Trading Arrangement Duration Entity Address, City or Town Entity Address, City or Town Award Timing MNPI Considered Award Timing MNPI Considered [Flag] Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration] Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration] Investing activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] Document Transition Report Document Transition Report Award Timing Predetermined Award Timing Predetermined [Flag] Business combination, consideration transferred, equity interests issued (in shares) Business Combination, Consideration Transferred, Equity Interests Issued And Issuable, Shares Business Combination, Consideration Transferred, Equity Interests Issued and Issuable, Shares Schedule of Business Acquisitions, by Acquisition [Table] Schedule of Business Acquisitions, by Acquisition [Table] License and royalty revenues License and Royalty Revenues [Member] License and Royalty Revenues [Member] Termination Date Trading Arrangement Termination Date Accounts payable Increase (Decrease) in Accounts Payable Common stock, shares authorized (in shares) Common Stock, Shares Authorized Repayments of debt Repayments of Lines of Credit Accrued Expenses and Other Liabilities and Other Long-Term Liabilities Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Probability of success Measurement Input, Probability Of Success [Member] Measurement Input, Probability Of Success DEFINITY DEFINITY [Member] DEFINITY [Member] Property, Plant and Equipment [Abstract] Property, Plant and Equipment [Abstract] Derivative Instrument [Axis] Derivative Instrument [Axis] Total principal outstanding Long-Term Debt, Gross Adjustments to reconcile net income to net cash flows from operating activities: Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] All Trading Arrangements All Trading Arrangements [Member] Measurement Input Type [Axis] Measurement Input Type [Axis] Bridge Loan Bridge Loan [Member] All Adjustments to Compensation All Adjustments to Compensation [Member] Derivative [Line Items] Derivative [Line Items] Award Timing Disclosures [Line Items] Compensation Amount Outstanding Recovery Compensation Amount Schedule of Operating and Finance Lease Assets and Liabilities Assets And Liabilities Lessee [Table Text Block] Assets And Liabilities Lessee 2022 Facility Covenants 2022 Facility Covenants [Member] 2022 Facility Covenants Other comprehensive income: Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Proceeds from stock option exercises Proceeds from Stock Options Exercised Statement of Comprehensive Income [Abstract] Statement of Comprehensive Income [Abstract] Convertible Debt Convertible Debt [Member] Finance lease liabilities Finance Lease, Liability 2026 Finite-Lived Intangible Asset, Expected Amortization, Year Three 2.625% Convertible Senior Notes due 2027 2.625% Convertible Senior Notes due 2027 [Member] 2.625% Convertible Senior Notes due 2027 Asset Retirement Obligation, Roll Forward Analysis [Roll Forward] Asset Retirement Obligation, Roll Forward Analysis [Roll Forward] Insider Trading Arrangements [Line Items] AOCI Attributable to Parent, Net of Tax [Roll Forward] AOCI Attributable to Parent, Net of Tax [Roll Forward] 2024 Long-Term Debt, Maturity, Year One Share price (in dollars per share) Share Price 2022 Term Facility 2022 Term Facility [Member] 2022 Term Facility Total operating expenses Operating Expenses Before Gain Loss On Sale Of Assets Operating Expenses Before Gain Loss On Sale Of Assets Entity Registrant Name Entity Registrant Name Schedule of Changes in Asset Retirement Obligations Schedule of Change in Asset Retirement Obligation [Table Text Block] Material Terms of Trading Arrangement Material Terms of Trading Arrangement [Text Block] Award Timing Method Award Timing Method [Text Block] Effect of dilutive share based compensation (in shares) Incremental Common Shares Attributable to Dilutive Effect of Share-Based Payment Arrangements Regulatory Milestones Regulatory Milestones [Member] Regulatory Milestones 2025 Finite-Lived Intangible Asset, Expected Amortization, Year Two Net sales targets - PYLARIFY (CVRs) Contingent Value Right [Member] Contingent Value Right Adjustment to Compensation, Amount Adjustment to Compensation Amount Cost of goods sold Cost of Sales [Member] Changes in fair value of contingent assets and liabilities Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability Document Period End Date Document Period End Date Compensation Actually Paid vs. Net Income Compensation Actually Paid vs. Net Income [Text Block] Peer Group Issuers, Footnote Peer Group Issuers, Footnote [Text Block] Adoption Date Trading Arrangement Adoption Date Less: accumulated depreciation and amortization Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment Schedule of Assets and Liabilities Measured at Fair Value on a Recurring Basis Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] Payments on long-term debt and other borrowings Repayments of Long-Term Debt Finance leases, weighted average discount rate Finance Lease, Weighted Average Discount Rate, Percent Finance Finance Lease, Liability, Noncurrent Treasury Stock Treasury Stock, Common [Member] Entity Central Index Key Entity Central Index Key Amortization of debt related costs Amortization of Debt Issuance Costs and Discounts Liabilities: Liabilities, Fair Value Disclosure [Abstract] Changes in fair value included in net (loss) income Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset, Gain (Loss) Included in Earnings Non-Rule 10b5-1 Arrangement Terminated Non-Rule 10b5-1 Arrangement Terminated [Flag] Cost Finite-Lived Intangible Assets, Gross Income tax expense Income tax expense Income Tax Expense (Benefit) Finished goods Inventory, Finished Goods, Net of Reserves Reconciliation to amounts within the condensed consolidated balance sheets Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations [Abstract] Finance Finance Lease, Right-of-Use Asset, after Accumulated Amortization Compensation and benefits Employee-related Liabilities, Current Valuation Approach and Technique [Domain] Valuation Approach and Technique [Domain] Fair Value of Financial Instruments Fair Value Disclosures [Text Block] Number of operating segments Number of Operating Segments Name Trading Arrangement, Individual Name Total other comprehensive (loss) income Other comprehensive (loss) income Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent Schedule of Disaggregation of Revenue Disaggregation of Revenue [Table Text Block] Accretion expense Asset Retirement Obligation, Accretion Expense Equity [Abstract] Equity [Abstract] Inventory Inventory Disclosure [Text Block] Operating leases, weighted average remaining lease term (in years) Operating Lease, Weighted Average Remaining Lease Term Revenues Revenue from Contract with Customer, Excluding Assessed Tax Compensation Actually Paid vs. Company Selected Measure Compensation Actually Paid vs. Company Selected Measure [Text Block] Long-term Debt, Type [Axis] Long-Term Debt, Type [Axis] Amendment Flag Amendment Flag Intangibles, Net Intangible Assets Disclosure [Text Block] Money market Money Market Funds [Member] Debt instrument, covenant percentage of additional interest Debt Instrument, Covenant Compliance, Percentage Of Additional Interest Upon Noncompliance Debt Instrument, Covenant Compliance, Percentage Of Additional Interest Upon Noncompliance Cash and Cash Equivalents [Axis] Cash and Cash Equivalents [Axis] Asset retirement obligations Asset retirement obligations, beginning balance Asset retirement obligations, ending balance Asset Retirement Obligations, Noncurrent Cash and cash equivalents Cash and cash equivalents Cash and Cash Equivalents, at Carrying Value Shares withheld to cover taxes (in shares) Share-Based Payment Arrangement, Shares Withheld for Tax Withholding Obligation Operating leases, weighted average discount rate Operating Lease, Weighted Average Discount Rate, Percent Licenses Licensing Agreements [Member] Assets: Assets, Fair Value Disclosure [Abstract] Credit Facility [Domain] Credit Facility [Domain] Fair Value Option, Disclosures [Table] Fair Value Option, Disclosures [Table] Debt instrument, basis rate Debt Instrument, Basis Spread on Variable Rate Compensation Actually Paid vs. Other Measure Compensation Actually Paid vs. Other Measure [Text Block] Contingent Consideration Type [Domain] Contingent Consideration Type [Domain] Finance leases, weighted average remaining lease term (in years) Finance Lease, Weighted Average Remaining Lease Term Finance Lease, Liability, Noncurrent, Statement of Financial Position [Extensible Enumeration] Finance Lease, Liability, Noncurrent, Statement of Financial Position [Extensible Enumeration] Sales and marketing Selling and Marketing Expense [Member] Diluted (in shares) Diluted weighted-average common shares outstanding (in shares) Weighted Average Number of Shares Outstanding, Diluted Forgone Recovery, Explanation of Impracticability Forgone Recovery, Explanation of Impracticability [Text Block] 2019 Term Loan Facility 2019 Term Loan Facility [Member] 2019 Term Loan Facility Asset Retirement Obligations Asset Retirement Obligation Disclosure [Text Block] Operating expenses Operating Expenses [Abstract] Revenue from Contracts with Customers Revenue from Contract with Customer [Text Block] Unrecognized tax benefits decrease resulting from settlements with taxing authorities Unrecognized Tax Benefits, Decrease Resulting from Settlements with Taxing Authorities Company Selected Measure Amount Company Selected Measure Amount Additional paid-in capital Additional Paid in Capital, Common Stock Additional Paid-In Capital Additional Paid-in Capital [Member] Total assets Assets Name Awards Close in Time to MNPI Disclosures, Individual Name Business combination contingent value right of total consideration Business Combination, Contingent Liability, Contingent Value Right, Consideration Business Combination, Contingent Liability, Contingent Value Right, Consideration Cover [Abstract] Cover [Abstract] Tax indemnification loss, net Tax Indemnification Agreement, Income (Expense) Represents the tax indemnification income (loss) earned during the period. Proceeds from convertible debt Proceeds from Convertible Debt 1404 Commercialization Milestone 1404 Commercialization Milestone [Member] 1404 Commercialization Milestone Stock-based compensation APIC, Share-Based Payment Arrangement, Increase for Cost Recognition Other long-term liabilities Total other long-term liabilities Other Liabilities, Noncurrent Non-NEOs Non-NEOs [Member] Construction in progress Construction in Progress [Member] Cash Flow Hedge Cash Flow Hedging [Member] Payments to acquire business Asset Acquisition, Consideration Transferred Segment Information Segment Reporting Disclosure [Text Block] Financial Assets Fair Value, Net Derivative Asset (Liability) Measured on Recurring Basis, Unobservable Input Reconciliation [Roll Forward] Net increase in cash, cash equivalents and restricted cash Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect Non-PEO NEO Non-PEO NEO [Member] Equity Component [Domain] Equity Component [Domain] Finance Finance Lease, Liability, Current Adjustment to Compensation: Adjustment to Compensation [Axis] Work in process Inventory, Work in Process, Net of Reserves Non-GAAP Measure Description Non-GAAP Measure Description [Text Block] Debt Instrument [Line Items] Debt Instrument [Line Items] Basic (in shares) Basic weighted-average common shares outstanding (in shares) Weighted Average Number of Shares Outstanding, Basic Entity Current Reporting Status Entity Current Reporting Status Unamortized debt issuance costs Unamortized Debt Issuance Expense Operating income Operating Income (Loss) Purchase price as a percentage of principal amount Debt Instrument, Redemption Price, Percentage of Principal Amount Redeemed Pay vs Performance Disclosure Pay vs Performance Disclosure [Table] Line of credit facility, unused capacity, commitment fee percentage Line of Credit Facility, Unused Capacity, Commitment Fee Percentage Operating activities Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] Statement [Line Items] Statement [Line Items] Payment for acquisitions Payments For Asset Acquisitions Payments For Asset Acquisitions Forgone Recovery due to Disqualification of Tax Benefits, Amount Forgone Recovery due to Disqualification of Tax Benefits, Amount Awards Close in Time to MNPI Disclosures Awards Close in Time to MNPI Disclosures [Table] Outstanding borrowings Long-Term Line of Credit Customer relationships Customer Relationships [Member]